The Assertional Metadata (AMD) contained within our Safety Intelligence Program (SIP) represents the largest ever-expanding collection of known effects of chemicals occurring in the different tissue, drugs effects on clinical biomarkers of tissue injury and drug molecular mechanisms.
A collaborative program for safety intelligenceThe Safety Intelligence Program is an industry-sponsored initiative that embraces the expertise of its pharmaceutical members and other stakeholders to build the world’s most comprehensive intelligence resource for use in improving drug safety assessments. Joining the program brings a wealth of benefits, including access to the Safety Intelligence System and participation in an interactive community under the Safety Intelligence Program Members Forum.
The Safety Intelligence System represents the largest forever-expanding collection of known effects of chemicals occurring in the different tissue, drugs effects on clinical biomarkers of tissue injury and drug molecular mechanisms.
The System currently contains almost 100,000 individual ‘facts’ assertions relating to the liver responses, affected by over 5,500 different compounds in over 20 different species. These assertions distill the observations and conclusions made across more than 19 million documents and database records, including regulatory documents, drug labels, pre-clinical and clinical research journals.
Using our intelligent search technology, we automatically ‘read’ millions of documents and store key observations as ‘assertional meta-data’. This meta-data is stored in a semantically consistent format which dramatically improves the pace and efficiency of analysis. Although millions of documents are read automatically, a task which would take hundreds of highly trained experts many months to achieve, we are able with rigorous quality control by PhD level scientists to deliver over 97% accuracy.
The Members Forum gives you the opportunity to interact with a rapidly expanding community of scientists (clinical or preclinical; chemist or biologists) all with a common interest in using the Safety Intelligence System to improve our understanding of mechanisms of drug-related adverse events. All Members have access to a series of large scale assertional meta-data analyses performed by us or other members and the opportunity to participate in a series of Webinars or other forms of interaction with other scientists. This creates the opportunity to learn from others about their applications of the Safety Intelligence System and the ever growing collection of assertional meta-data.
The Safety Intelligence System is accessible using an internet explorer from anywhere in the world.
As well as the usual ‘quick search’ box for keyword searching, the system allows searching by chemical structure. Advanced ‘assertional meta-data’ searching is also possible, for example, you can search for all compounds causing liver necrosis in seconds. Our unique format of ‘assertional meta-data’ allows you to complex analyses to be performed.
Any search can be saved as a favourite to speed up future searching and the system has in-built alerting functionality so you will be automatically notified of any changes in the data that impact a saved query.
The content of the Safety Intelligence System is expanding daily. In the next three months, we will expand the assertional meta-data in the System to other tissues, starting with the cardiac system, followed by kidney. The list of data sources used is also expanding, we are currently working on the FDA New Drug Applications for liver effects – this will also be available in the next 3 months. The content grows according to the sponsorship of our Charter Members. As a Charter Member, you prioritise what is created built and when; in return Charter Members receive perpetual rights to the data.
If you are already a member, you can access SIP here.
For a free trial of SIP, please email us at sip@biowisdom.com.
Download the membership options leaflet.
Alternatively, email sip@biowisdom.com for more information or if you would prefer to contact us directly, please call our telephone sales department, United Kingdom +44 (0)1223 874838. Our telephone sales are open during normal office hours 09:00 to 17:30, Monday through Friday.
You can access all SIP demonstrations and tutorials here or you can download the videos below.
 |
Safety Intelligence Program Overview |
|
SIP Quick Search Tutorial - Compounds that cause fibrosis |
|
SIP Chemistry Search - The effects of bromobenzene compounds in the human liver |
|
SIP Advanced Search Tutorial - Investigating the role of Carboxylic Acids in Hepatotoxicity |
You can access all SIP webinars here.
This webinar introduces the Safety Intelligence Program, discussing current strengths and future directions.
 | BioWisdom SIP Webinar 11 February 2009 |
|
BioWisdom SIP Webinar 11 February 2009 Slides |
In this SIP series webinar Dave Cook from Astrazeneca’s Global Safety Assessment Team presents Astrazeneca’s experience of using SIP.
| BioWisdom SIP Webinar 15 Jan 2009 |
|
BioWisdom SIP Webinar 15 Jan 2009 - AstraZeneca slides |
In this webinar Prof. Alex Thropsha and Dr. Denis Fourches from University of North Carolina present their work on chemoinformatics analysis performed using SIP.
| BioWisdom SIP Chemoinformatics Webinar 11 Nov 2008 |
|
BioWisdom SIP Chemoinformatics Webinar 11 Nov 2008 Slides |
This SIP webinar presents how a better understanding of hepatobiliary transport inhibition can be obtained using SIP.
| BioWisdom SIP Webinar 23 Oct 2008 |
|
BioWisdom SIP Webinar 23 Oct 2008 Slides |
In this video you will see an overview of the Safety Intelligence Program’s web interface. The tutorial includes:
The tour takes just under 3 minutes to run. Use the controls at the bottom of the screen to pause or rewind the video.
| Safety Intelligence Program Overview |
In this tutorial we will use the Safety Intelligence System to identify those compounds that cause fibrosis in the liver. It includes:
The tutorial lasts for just over 2 minutes.
| SIP Quick Search Tutorial - Compounds that cause fibrosis |
In this tutorial, we will use some of the advanced search capabilities of the Safety Intelligence System to investigate how carboxylic acids may be involved in hepatotoxicity. Do they show an unusual profile compared to compounds that do not contain a carboxylic acid sub-structure? Is there a particular type of hepatotoxic affect, e.g. oxidation or oxidative stress. The tutorial will take around 5 minutes to complete. You can also download below the poster presented at the Society Of Toxicology, Seattle, 2008. In performing this analysis we will use:
| SIP Advanced Search Tutorial - Investigating the role of Carboxylic Acids in Hepatotoxicity |
|
Safety Intelligence Program - Carboxylic Acids Study |