About the Safety Intelligence Program
Wednesday, February 17th, 2010
A collaborative program for safety intelligence
The Safety Intelligence Program is an industry-sponsored initiative that embraces the expertise of its pharmaceutical members and other stakeholders to build the world’s most comprehensive intelligence resource for use in improving drug safety assessments. Joining the program brings a wealth of benefits, including access to the Safety Intelligence System and participation in an interactive community under the Safety Intelligence Program Members Forum.
An unparalleled resource for drug safety
The Safety Intelligence System represents the largest forever-expanding collection of known effects of chemicals occurring in the different tissue, drugs effects on clinical biomarkers of tissue injury and drug molecular mechanisms.
The System currently contains almost 100,000 individual ‘facts’ assertions relating to the liver responses, affected by over 5,500 different compounds in over 20 different species. These assertions distill the observations and conclusions made across more than 19 million documents and database records, including regulatory documents, drug labels, pre-clinical and clinical research journals.
Using our intelligent search technology, we automatically ‘read’ millions of documents and store key observations as ‘assertional meta-data’. This meta-data is stored in a semantically consistent format which dramatically improves the pace and efficiency of analysis. Although millions of documents are read automatically, a task which would take hundreds of highly trained experts many months to achieve, we are able with rigorous quality control by PhD level scientists to deliver over 97% accuracy.
Members Forum: A Global community
The Members Forum gives you the opportunity to interact with a rapidly expanding community of scientists (clinical or preclinical; chemist or biologists) all with a common interest in using the Safety Intelligence System to improve our understanding of mechanisms of drug-related adverse events. All Members have access to a series of large scale assertional meta-data analyses performed by us or other members and the opportunity to participate in a series of Webinars or other forms of interaction with other scientists. This creates the opportunity to learn from others about their applications of the Safety Intelligence System and the ever growing collection of assertional meta-data.
An intuitive search interface
The Safety Intelligence System is accessible using an internet explorer from anywhere in the world.
As well as the usual ‘quick search’ box for keyword searching, the system allows searching by chemical structure. Advanced ‘assertional meta-data’ searching is also possible, for example, you can search for all compounds causing liver necrosis in seconds. Our unique format of ‘assertional meta-data’ allows you to complex analyses to be performed.
Any search can be saved as a favourite to speed up future searching and the system has in-built alerting functionality so you will be automatically notified of any changes in the data that impact a saved query.
Coming soon….
The content of the Safety Intelligence System is expanding daily. In the next three months, we will expand the assertional meta-data in the System to other tissues, starting with the cardiac system, followed by kidney. The list of data sources used is also expanding, we are currently working on the FDA New Drug Applications for liver effects – this will also be available in the next 3 months. The content grows according to the sponsorship of our Charter Members. As a Charter Member, you prioritise what is created built and when; in return Charter Members receive perpetual rights to the data.
I attended a virtual conference last week, hosted by the